THE SCHOLARS
By Discipline
Cancer Biology
Cancer biology focuses on the mechanisms that underlie fundamental processes such as cell growth, the transformation of normal cells to cancer cells, and the spread, or metastasis, of cancer cells.
DR. PAMELA KREEGER
UW Department of Biomedical Engineering
Ovarian Cancer
In order to stop the spread of the tumors throughout the body, Dr. Kreeger's research seeks to understand how tumor cells detach from a tumor to initiate metastasis. In particular, her research will focus on why some cells will detach as a cluster rather than as individual cells – a choice that gives them a survival advantage against both natural defenses and chemotherapy.
Cancer Genomics
Cancer is a disease of gene mutation. Understanding these mutations that drive cancer leads to a better awareness of how cancer arises and spreads to distant organs.
DR. JOHN DENU
UW Department of Biomolecular Chemistry
Prostate Cancer
Dr. Denu’s research program centers on targeting DNA as a strategy to kill cancer cells. Oncogenic protein NSD2 has recently emerged as a therapeutic target, however no effective inhibitors exist because of poor molecular understanding. The goal of Dr. Denu's research is to determine the molecular Achilles heel of NSD2, paving the way for NSD2 inhibitors to treat prostate and other cancers.
DR. MARK BURKARD
UW Department of Medicine
Breast Cancer
Dr. Mark Burkard is part of the UWCCC Precision Medicine Molecular Tumor Board where clinicians, pathologists and scientists work collaboratively to recommend patient-specific targeted therapies. This collaborative group of experts from around the state serves as a resource to evaluate the meaning and context of genomic information about a patient’s tumor in order to recommend better treatment that will positively impact survival rates.
Cancer Imaging
Detecting cancer at its earliest stages is fundamental for early treatment and increasing cure rates.
DR. JESSICA MILLER
UW Department of Human Oncology
Liver Cancer | Pancreatic Cancer
Dr. Miller's research specializes in using modern CT Scan imaging to improve the precision of radiation therapy delivery to tumors. This new imaging has the capability to perform dual-energy CT (DECT), which has the potential to improve tumor visualization in challenging anatomical sites like the pancreas and liver. Dr. Miller's goal is that through dedicated DECT research, her team can improve patient imaging and ultimately help save patient lives.
DR. EDWARD JACKSON
UW Department of Medical Physics
Dr. Jackson is collaborating with Drs. Matt Witek, Tabby Kennedy and Greg Avey to more precisely image head and neck cancers to improve future treatment approaches for these complex patients. UW is one of the few sites in the United States to have access to a combined PET/MRI scanner. This device gives our researchers and physicians access to incredibly high resolution images of the tumor, while simultaneously providing metabolic and cellular level data. Dr. Jackson and team are investigating ways to use this device to improve tumor targeting with radiotherapy and also ways to use this information to decrease treatment toxicity.
DR. HAU LE
UW Department of Surgery
Lung Cancer | Pediatric Cancer
In collaboration with Drs. J. Leon Shohet, Ha Nguyen, Mario Otto and Christian Captini, Dr. Le's research brings together a team of engineers, oncologists, and a surgeon to design and build an innovative cold atmospheric plasma device that can kill cancer cells without harming normal surrounding tissue. The device can be used in the operating room to destroy cancer cells left behind during surgery or to extend surgery to patients who have cancer but are traditionally deemed inoperable.
Drug Design
Finding new treatments based on biological targets via algorithms, large amounts of data and technologies significantly improves the effectiveness of new and existing drugs.
Immunooncology
Harnessing the body’s own defenses to recognize cancer cells and destroy them.
DR. DUSTIN DEMING
UW Department of Medicine
Colorectal Cancer
Dr. Deming's research focuses on combining DNA targeting and immunotherapy in the treatment of colorectal cancer. Currently immunotherapeutics are only beneficial for a small subset of patients with colorectal cancer who have deficiencies in DNA mismatch repair. Dr. Deming's lab has recently generated data indicating the potential to enhance the immune response using precision medicine-based therapies. His team will now utilize murine and patient-derived spheroid cultures to screen targeted therapies for their potential to enhance the immune response to immune checkpoint blockade.
DR. XIAOFEI ZHANG
UW Department of Pathology
Pancreatic Cancer
Dr. Zhang's work focuses on harnessing the immune system to treat pancreatic cancer. Pancreatic cancer is the fourth deadliest cancer in US, but the second deadliest cancer in Wisconsin. It is one of the hardest-to-treat cancer because of its dense “scar-like” stroma which prevent treatment and immune surveillance. Dr. Zhang's research focuses on finding a way to break down the storma and make pancreatic cancer cells targetable by immunotherapy. If it works, this strategy will provide guidance to design more effective combinational therapy strategy to benefit pancreatic cancer patients in Wisconsin and all over the world.
NanoMedicine
Researchers at UW are designing new medicines that home in on your cancer and deliver specific treatments leading to decreased side effects and increase cure rates.
Population Health
A customizable approach that allows researchers and healthcare professionals to connect practice to policy through non-traditional partnerships among different sectors of the healthcare community.
HASAN NADEEM
Student Scholar - Dr. Shaneda Warren Anderson's Lab
Breast Cancer
Hasan's work investigates why breast cancer incidence, mortality, and survival differ across race/ethnicity, geography, and socioeconomic status. This research aims to create a more equitable treatment paradigm and reduce disparities within breast cancer care.
Precision Medicine
Although we often define cancer by the organ in which it arises, there are over 100 types of unique cancers. Research at UW propels our understanding of your individual tumor so we can personalize your therapy.
DR. BETH WEAVER
UW Department of Cell and Regenerative Biology
Breast Cancer
Dr. Weaver's research aims to identify a biomarker to predict which patients will benefit from treatment with the commonly used chemotherapy drug paclitaxel (TaxolTM). Such a biomarker could assist in identifying the optimal therapy for individual patients.
DR. DAVID BEEBE
UW Department of Biomedical Engineering
Head & Neck Cancer
Dr. Beebe's work includes the development of 3D in vitro models that can recapitulate in vivo geometry and interactions present in the lymphatic system in head and neck cancer and allow for improved study of HNC metastasis via the lymphatics. Specifically, his research expands his lab's patient-derived lymphatic vessel model for studying lymphatic vessel interactions with HNCCs and the tumor microenvironment to evaluate its potential for informing personalized therapy.
DR. JOSH COON
UW Department of Chemistry
Dr. Coon develops cutting-edge chemical instrumentation to measure proteins in human cells and tissues. In collaboration with Professor Mark Burkard, Dr. Coon's lab will investigate chromosome instability (CIN)-a common feature of diverse cancers-to identify protein changes at the cellular level that regulate chromosomes. This information will identify the biomarkers needed to better target therapies.
DR. NOELLE LOCONTE
UW Department of Medicine
Colon Cancer | Liver Cancer | Pancreatic Cancer
Dr. LoConte's works to increase efforts in reducing high risk alcohol use, improving HPV vaccination rates and increase recommended cancer screening tests across Wisconsin.
DR. MELISSA SKALA
UW Department of Biomedical Engineering
Breast Cancer | Colorectal Cancer | Head & Neck Cancer | Pancreatic Cancer
Dr. Skala aims to develop technologies that can customize immunotherapies for each patient, so that more breast cancer patients can achieve robust, long-lasting remissions. Her work has established new optical imaging technologies that can predict breast cancer response to chemotherapy and targeted therapies and looks to further develop optical imaging technologies to assess response to immunotherapies in patient samples.
DR. KRISTINA MATKOWSKYJ
UW Department of Pathology and Laboratory Medicine
Dr. Matkowskyj focuses on building upon the existing infrastructure within the Translational Science BioCore (TSB) to optimize patient consenting, increase tissue donation to the BioBank, expedite the creation of research resources (i.e., tissue microarrays) and improve the utilization of biospecimens by our UW Carbone Cancer Center investigators. Her work will lead to improvement in cancer patient health.
DR. RONG HU
UW Department of Pathology and Laboratory Medicine
HEAD & NECK CANCER
Dr. Hu's research focuses on Tissue microarrays (TMA) which are powerful tools used to study cancer biomarkers for cancer diagnosis, prognosis and treatment prediction. Currently, she's building multiple head and neck cancer TMAs from different anatomic sites to support UW head and neck cancer research.
DR. SHIGEKI MIYAMOTO
UW Department of Oncology
Blood Cancer
Dr. Miyamotos research focuses on identifying novel biomarkers to predict and treat aggressive forms of multiple myeloma (MM). In conjunction with Drs. Lingjun Li and Natalie Callander, this collaborative research aims to develop a drug that will target a drug resistant factor in order to offer effective therapies to MM patients.
DR. SUSAN PITT
UW Department of Surgery
Thyroid Cancer
Dr. Pitt's work focuses on improving treatment strategies for thyroid cancer. Her work focuses on why surgeons and patients choose extensive treatment that can have long-term consequences for low-risk thyroid cancer. Dr. Pitt's study will help adapt a decision-support intervention used in other cancer patients for use in low-risk thyroid cancer in order to give patients the best treatment options.
Radiation Therapy
Researchers at UW have pioneered advances in the delivery of radiation precisely to the tumor and not normal tissue.
DR. BETHANY ANDERSON
UW Department of Human Oncology
Breast Cancer
Radiation therapy can cause fibrosis (scar tissue) to form and reduce the blood supply of a treated area, which may increase the risk for surgical complications and a worse long-term cosmetic outcome. Dr. Anderson works with colleagues in the plastic surgery department to perform a clinical study using oral medicines given during and after radiation therapy showing promise in reducing fibrosis. Her research also focuses on studying biomarkers for scar tissue formation.
DR. STEVEN HOWARD
UW Department of Human Oncology
Brain Cancer
Dr. Howard's research focuses on how cancers develop therapy resistance and developing strategies to reverse resistance.
DR. JENNIFER SMILOWITZ
UW Department of Human Oncology
Dr. Smilowitz performs cutting edge research on next generation radiation treatment machines to further improve treatment outcomes for cancer patients.
IAN MARSH
Student Scholar - Dr. Bryan Bednarz's Lab
Marsh works in the laboratory of Dr. Bryan Bednarz studying how external beam radiation can be combined with molecular targeted radionuclides to advance cancer treatment in primary and metastatic tumors.
DR. BRYAN BEDNARZ
UW Department of Medical Physics
Dr. Bednarz researches the impact of radiation emitted from radioactive drugs on tumor cells and their surroundings.
DR. ZACHARY MORRIS
UW Department of Human Oncology
Breast Cancer | Colon Cancer
Dr. Morris investigates a new approach to cancer treatment, in which radiation will be delivered to a single tumor site and then injected into that site with agents that stimulate the immune system to recognize and kill tumor cells. Preliminary data suggests that this combined treatment may act like an anti-cancer vaccine, resulting in both a local and systemic anti-tumor response. This approach may improve the response to existing cancer immunotherapies and is therefore potentially relevant to the treatment of nearly any type of cancer.
Targeted Therapies
Understanding what proteins drive cancer is critical and such advances will lead to cures.
DR. PETER LEWIS
UW Department of Biomolecular Chemistry
Head & Neck Cancer
High-grad pediatric gliomas are among the leading causes of cancer death in children and Dr. Lewis' research points to aberrant chromosome structure as a previously unsuspected driver of these intractable tumors. The goal of his research is to illuminate the molecular mechanisms that underlie Histone H3 mutations in order to advance the exploration of therapeutic avenues.
MARK KLEIN
Student Scholar - Dr. John Denu's Lab
Klein's research focuses on developing therapies that combat the growth of cancer cells by targeting epigenetic factors. His research will evaluate changes in the epigenetic modifications of histones, monitor global changes in histone modifications and evaluate cellular updates of small-molecules following treatment.
YOUSEF ALHARBI
Student Scholar - Dr. Patankar's Lab
Ovarian Cancer
Alharbi’s research is exploring the mechanism of novel drugs that kill cancer cells by preventing them from maintaining a normal ionic balance across their cell membrane. These novel drugs include a new class of antibody and natural compound--a small molecule agent extracted from the root of the plumbagin plant.
DR. MARIO OTTO
UW Department of Pediatrics
Pediatric Cancer
Dr. Otto and his research group is pursuing novel, alternative approaches to treat childhood cancer. His research includes areas such as adoptive immunotherapies, stem cell graft engineering and molecular targeting of cancers with nanoparticles and small anti-cancer molecules.
DR. ANJON AUDHYA
UW Department of Biomolecular Chemistry
Breast Cancer
The goal of Dr. Audhya's work is to determine whether inhibiting the intracellular movement of key factors that promote metastasis can serve as a new therapeutic strategy for the treatment of metastatic cancers in patients.
Therapeutic Resistance
Understanding and predicting how tumors become resistant to different therapies is vital to prolonging life and curing patients.
DR. SHIGEKI MIYAMOTO
UW Department of Oncology
Blood Cancer
Dr. Miyamoto researches how cancers develop therapy resistance and developing strategies to reverse resistance.
DR. JOSH LANG
UW Department of Medicine
Prostate Cancer
Dr. Lang studies Circulating Tumor Cells to detect cancer at an early stage and develop new treatment approaches for resistant cancers. Through the use of cutting edge microfluidic technology, Dr. Lang has been able to capture cancer cells from a blood draw (instead of a biopsy) to test how cancers become resistant to our current therapies. His research will test these samples to identify men that may benefit from a new class of drugs being developed to target treatment resistant prostate cancers.
DR. RANDY KIMPLE
UW Department of Human Oncology
Head & Neck Cancder
Dr. Kimple's research focuses on using mesenchymal stem cells (MSCs) to treat radiation-induced xerostomia. Working with Dr. Jacques Galipeau and the Program for Advanced Cell Therapy, Dr. Kimple's lab seeks to study the MSCs from head and neck cancer patients who have completed radiation to ensure they are capable of being used as a personalized therapy. This pilot study will lay the groundwork for a FDA-IND application and a first-in human clinical trial to treat xerostomia.
Viral Oncology
Over 25% of all cancers are caused by viral infection and UW researchers are leading the way in methods for detection, treatment and prevention of viral-driven cancer.
DR. PAUL AHLQUIST
UW Department of Plant Pathology
Cervical Cancer
Dr. Ahlquist studies how viruses cause certain cancers and developing new approaches to improve future treatments for these cancers. Dr. Ahlquist and his collaborators are revealing novel interactions by which papillomavirus-induced cervical cancer cells exchange detailed signals with surrounding, non-cancerous stromal cells, creating a supportive tumor micro-environment essential to tumor development and persistence. The results are providing valuable insights for understanding, diagnosing and controlling cervical cancers, which are still a leading cause of cancer death for women worldwide.
TAO WEI
Student Scholar - Dr. Paul Lambert's Lab
Head & Neck Cancer
Wei's research in Dr. Paul Lambert's lab focuses on head and neck cancer which is the sixth most common cancer worldwide. In her research, Wei discovered how a particular gene expression in head and neck cancer contributes to this type of cancer and is working to identify new drug targets that could lead to new therapies to patients.
DR. NATHAN SHERER
UW Department of Oncology
Anogenital Cancer | Cervical Cancer | Head & Neck Cancer
Dr. Sherer is working in collaboration with Dr. Evie Carchman to identify new targets for treating virus-driven cancers. Human papillomavirus (HPV) is the most commonly diagnosed sexually-transmitted disease in Wisconsin and the United States and an estimated 79 million Americans are HPV-positive and at elevated risk for deadly HPV associated oral and anogenital cancers. Dr. Sherer's project will determine if FDA-approved protease inhibitors currently used to treat HIV/AIDS can be repurposed to treat or prevent HPV-associated cancers.
